Maitake D-fraction


Maitake ~ The King of Mushrooms
Maitake mushroom (Grifola frondosa), indigenous to northern part of Japan, has been prized in traditional Japanese culture for hundreds of years. It is a premier culinary delicacy as well as medicinal mushroom of great vitality.
Researchers and clinical experiences have identified Maitake D-Fraction (containing beta-1,3 glucan and beta-1,6 glucan) as active component that provide nutritional support for cellular immune function.
Maitake is an effective immunoceutical. Its functions include:
  • Alleviate the side effects associated with cancer treatments
  • Improve the patients’ well-being during radiotherapy and  chemotherapy
  • Enhance and regulate the immune system of body
[Summary of Scientific Researches]
Numerous studies have confirmed that maitake has prominent beneficial effects on immune function. It promotes the action of not only macrophages, but also a variety of other immune-related cells, such as natural killer (NK) cells and cytotoxic T-cells (TC) that can attack tumor cells. Maitake also increases the immune-related efficiency of these cells by increasing interleukin-1, interleukin-2, and lymphokines. The end result is an increased defense against cancer.
Maitake researchers have identified several ways maitake can counter cancer:
1.            By protecting healthy cells from becoming cancerous
2.            By helping to prevent cancer metastasis
3.            By slowing or stopping the growth of tumors
[Summary of Clinical Trials]
Maitake can work in conjunction with chemotherapy to lessen its side effects, such as hair loss, pain, and nausea, and to boost its positive effects.
In a clinical study with participation of a total of 165 cancer patients in stage III-IV, one group of patients was administered Maitake D-Fraction along with chemotherapy, and the other group received chemotherapy only. The results suggest that breast, lung, and liver cancers were improved by maitake. Most of the patients under the maitake treatment claimed improvement of overall symptoms. Various side effects from chemotherapy such as lost appetite, vomiting, nausea, hair loss, and leucopenia (deficiency of white blood cells) were ameliorated by 90% of the patients. Reduction of pain was also reported by 83% of the patients.
   Maitake D-Fraction  
Grifron® Maitake D-Fraction Extract
(Suitable for patients receiving radiotherapy or chemotherapy)
Each standardized preparation of 30ml bottle contains at least 900mg pure, active beta-glucans originated from Maitake fruit-body. There is approximately 820 drops of liquid in the 30ml bottle.
Three times daily. For better absorption, take with an empty stomach. To maximize beneficial effects, take Maitake Caplets with Maitake D-Fraction Extract.
Refer to the following table for dosage information:


During Treatment
/After Treatment
Prevention or After Recovery
over 120lbs
25 drops
20 drops
5 drops
once daily
20 drops
15 drops
below 100lbs
15 drops
12 drops


                      Maitake Caplets
Grifron® Maitake Caplet
(Suitable for Prevention and After Recovery)       
Each caplet contains 500mg whole Maitake mushroom fruit body. Nutrients include Maitake D-Fraction, Vitamin C, B2, D2, Niacin, minerals, fibre and amino acids. 100 caplets per package.
Maitake Caplets also contain SX-Fraction which could be used as an adaptogen. This is particularly suitable for patients with hypertension, diabetes mellitus, and hyperlipidemia .
For maintenance, 2 caplets once daily. To maximize beneficial effects, take 1 Maitake Caplet with Maitake D-Fraction Extract, three times daily. For better absorption, take with an empty stomach.
[Product Authenticity]
Grifron® Maitake D-Fraction is generally regarded as safe with no serious adverse reactions. Its excellent safety profile received FDA exemption of Phase I toxicity data. In February 1998, FDA approved an Investigation New Drug Application (IND#54,589) for researchers to conduct a Phase II pilot study on Maitake D-Fraction's potential effects on advanced breast and prostate cancer.
Grifron® Maitake D-Fraction Extract or Grifron® Maitake Caplet are contraindicated in patients hypersensitivity to Maitake or any of the inactive ingredients in the preparations.
Potential for interaction with immunosuppresants. Numerous in-vitro studies have demonstrated that Maitake has immunomodulatory actions. Although there are no reports describing the interactions with immunosuppresants, it is recommended that Maitake preparations should not be used in combination with immunosuppressants.



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